In vivo is a Latin term that refers to experiments, studies, or processes that occur within a living organism such as animals and humans. For example, scientists can study disease development or impact of a drug treatment in a whole organism by using in vivo models such as mice as model organisms. In vivo models are essential for undertanding biological processes and to capture the complexity of interactions in various biological levels. These range from interactions between different cell types to systemic responses affecting the whole organism.
The use of in vivo models must always be ethically approved. This is evaluated by comparing the potential harm to the living organism against benefit that is gained by the use of the model. Additionally, research with in vivo models requires highly trained research personnel and specialised facilities.
This entry was provided by the doctoral students of the GetRADI collaborative network. GetRADI is funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.